Article Sidebar

Submitted
October 21, 2024
Accepted
October 21, 2024
Published
October 21, 2024
Download
PDF
Statistic
Read Counter : 487 Download : 303

Main Article Content

Abstract

Background: Insulin resistance in the insulin target tissue and insufficient insulin production by pancreatic
β-cells are the hallmarks of chronic type 2 diabetes mellitus (T2DM). Certain INPPL1 gene variants have
been associated with type 2 diabetes in Indian, Japanese, British, and French populations, according to
researches.
Objectives: Evaluate the relationship between the risk of type 2 diabetes mellitus (T2DM) in the AL-Najaf
community and single nucleotide polymorphisms (SNPs) in the INPPL1 gene.
Methods: A case-control research was conducted with a sample size of 200 individuals. The INPPL1 gene's
single nucleotide polymorphism (+1893CC/AA) was genotyped using the PCR-RFLP technique.
Results: The frequency of the A allele (p < 0.001) was shown to be considerably greater in T2DM patients,
and SNP +1893CC/AA was found to be strongly linked with T2DM.
Conclusion: The vulnerability of the AL-Najaf community to type 2 diabetes mellitus has been strongly
connected to the single nucleotide polymorphism (+1893CC/AA) in the INPPL1 gene, according to the
results.

Keywords

Type 2 diabetes mellitus INPPL1 Gene polymorphism

Article Details

License

Copyright (c) 2024 University of Thi-Qar Journal Of Medicine

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

References

  1. Care D, Suppl SS. 2. Classification and diagnosis of diabetes: Standards of medical care in diabetes2021. Diabetes Care. 2021;44(January):S15–33.
  2. Falih Z, Alzubaidi M. Association of calpain-10 gene polymorphism with type 2 diabetes mellitus
  3. in Iraqi patients. 2021;
  4. Bhatty A, Baig S, Fawwad A, Rubab ZE, Shahid MA, Waris N. Association of Zinc Transporter-8
  5. Autoantibody (ZnT8A) with Type 1 Diabetes Mellitus. Cureus. 2020;12(3):1–8.
  6. Duarte‐Díaz A, Himar González‐Pacheco MSc, PhD AR, Yolanda Ramallo‐Fariña MSc, Lilisbeth
  7. Perestelo‐Pérez MPsych PP. Factors associated with patient empowerment in Spanish adults with type 2
  8. diabetes: A cross‐sectional analysis. Heal Expect. 2022;(March).
  9. Yujing. Research progress on gestational diabetes mellitus and endothelial dysfunction markers.
  10. Diabetes, Metab Syndr Obes Targets Ther. 2021;14:983–90.
  11. Gilor C, Niessen SJM, Furrow E, DiBartola SP. What’s in a Name? Classification of Diabetes
  12. Mellitus in Veterinary Medicine and Why It Matters. J Vet Intern Med. 2016;30(4):92740.
  13. Chobanyan N, Allison Kruger K, Nebb S, Jackson G, Asin V. Evaluation of environmental risk
  14. factors for type 2 diabetes in Sint maarten. J Env Anal Toxicol. 2016;6(386):525–2161.
  15. Lytrivi M, Castell A-L, Poitout V, Cnop M. Recent insights into mechanisms of β-cell lipo-and
  16. glucolipotoxicity in type 2 diabetes. J Mol Biol. 2020;432(5):1514–34.
  17. Dendup T, Feng X, Clingan S, Astell-Burt T. Environmental risk factors for developing type 2
  18. diabetes mellitus: a systematic review. Int J Environ Res Public Health. 2018;15(1):78.
  19. Herder C, Roden M. Genetics of type 2 diabetes: pathophysiologic and clinical relevance. Eur J
  20. Clin Invest. 2011;41(6):679–92.
  21. Hoang Do O, Thorn P. Insulin secretion from beta cells within intact islets: location matters. Clin
  22. Exp Pharmacol Physiol. 2015;42(4):406–14.
  23. Jerram ST, Leslie RD. The genetic architecture of type 1 diabetes. Genes (Basel). 2017;8(8).
  24. McCarthy MI. Genomics, type 2 diabetes, and obesity. N Engl J Med. 2010;363(24):233950.
  25. Mubarak SMH, Al-Koofee DAF, Al-Zubaidy HFS, Mohammed SB, Al-Zubaidy ZF. PIRA-PCR
  26. technique is a resolve for any unavailable restriction enzyme of single nucleotide polymorphism. Ann Trop
  27. Med Public Heal. 2020;23(18):16–20.
  28. Badiu C. Williams textbook of endocrinology. Acta Endocrinol. 2019;15(3):416.
  29. Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, et al. Human chromosome 11
  30. DNA sequence and analysis including novel gene identification. Nature. 2006;440(7083):497–500.
  31. Fradet A, Fitzgerald J. INPPL1 gene mutations in opsismodysplasia. J Hum Genet.
  32. ;62(2):135–40.
  33. Ishida S, Funakoshi A, Miyasaka K, Shimokata H, Ando F, Takiguchi S. Association of SH-2
  34. containing inositol 5′-phosphatase 2 gene polymorphisms and hyperglycemia. Pancreas. 2006;33(1):63–7.
  35. Habib T, Hejna JA, Moses RE, Decker SJ. Growth factors and insulin stimulate tyrosine
  36. phosphorylation of the 51C/SHIP2 protein. J Biol Chem. 1998;273(29):18605–9.
  37. Kagawa S, Sasaoka T, Yaguchi S, Ishihara H, Tsuneki H, Murakami S, et al. Impact of Src
  38. homology 2-containing inositol 5′-phosphatase 2 gene polymorphisms detected in a Japanese population on
  39. insulin signaling. J Clin Endocrinol Metab. 2005;90(5):2911–9.
  40. Vanhaesebroeck B, Alessi DR. The PI3K–PDK1 connection: more than just a road to PKB.
  41. Biochem J. 2000;346(3):561–76.
  42. Sleeman MW, Wortley KE, Lai K-M V, Gowen LC, Kintner J, Kline WO, et al. Absence of the
  43. lipid phosphatase SHIP2 confers resistance to dietary obesity. Nat Med. 2005;11(2):199–205.
  44. Hao YM, Liu QJ, Wang RY, Cao YP, Zhang Y, Zuo LF. Single nucleotide polymorphisms on
  45. SHIP2 is associated with Type 2 diabetes mellitus in Chinese Han population. Eur Rev Med Pharmacol Sci.
  46. ;19(1):129–37.
  47. Singh J, Kumar V, Bala K, Aneja A, Singh J. Associations of INPPL1 (+1893CC/AA and +
  48. AA/GG) exonic polymorphisms with the risk of type 2 diabetes mellitus in North Indian population: A
  49. case control study. Meta Gene [Internet]. 2021;29(February):100929. Available from:
  50. https://doi.org/10.1016/j.mgene.2021.100929
  51. Yau M, Maclaren NK, Sperling MA. Etiology and pathogenesis of diabetes mellitus in children
  52. and adolescents. Endotext [Internet]. 2021;
  53. Mizukami H, Kudoh K. Diversity of pathophysiology in type 2 diabetes shown by islet pathology.
  54. J Diabetes Investig. 2022;13(1):6–13.
  55. Artasensi A, Pedretti A, Vistoli G, Fumagalli L. Type 2 diabetes mellitus: a review of multi-target
  56. drugs. Molecules. 2020;25(8):1987.

Similar Articles

You may also start an advanced similarity search for this article.