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November 29, 2023
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November 29, 2023
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November 29, 2023
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Abstract

Cutaneous Leishmaniasis represents one of the widespread epidemic disease in Iraq
caused by the protozoan Leishmania parasite. However, There are clinical difficulties in
distinguish between this disease and other skin diseases can leave permanent skin scars.
This study aims to identify potential biomarkers for Cutaneous Leishmaniasis diagnosis
and prognosis and to know the progression of the disease and the distribution of
inflammation within the skin cells. In this review, 17 proteins have been selected using
literature searching such as pubmed and web of science to identify potential biomarkers
for Cutaneous Leishmaniasis diagnosis and prognosis and further studies needed to find
the role of these protein in the development of the disease.

Keywords

Cutaneous Leishmaniasis biomarkers

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References

  1. Silva, H., Liyanage, A., Deerasinghe, T., Sumanasena, B., Munidasa, D.,
  2. de Silva, H., and Karunaweera, N. (2021). Therapeutic response to thermotherapy in cutaneous
  3. leishmaniasis treatment failures for sodium stibogluconate: a randomized controlled proof of
  4. principle clinical trial. The American J. Trop. Med and Hygiene , 104 (3) , 945 - 950 pp.
  5. Al-Yasiri, F. J. M., Alghezi, D. A., & Al-Abadi, F. A. M. (2022). Diagnostic
  6. usefulness of immunohistochemical (IHC) assessment of CD1a and CD68 biomarkers for
  7. cutaneous leishmaniasis. International Journal of Health Sciences, 6(S7), 3605–3613.
  8. https://doi.org/10.53730/ijhs.v6nS7.12590
  9. Georgiadou,SP;Makaritsis,K.P;and Dalekos,G.N. (2015). Leishmaniasis
  10. revisited : Current aspect on epidemiology ,diagnosis and treatment J. trans. Int. med .3 (2): 43 -
  11. pp.
  12. Wamai, R.G.; Kahn, J.; McGloin, J.; and Ziaggi, G. (2020). Visceral Leishmaniasis:
  13. A Global overview , J .Glob. Heal. Sci., 2 (1): 1- 22 pp.
  14. Al-Nahas ,S.(2006). Isoenzyme typing and leishmaniasis diagnosis. J. labrotory
  15. diagnostics. 4 (2),1 - 8 pp.
  16. Ghorbani, M and Farhoudi R. ( 2018). Leishmaniasis in humans: drug or vaccine
  17. therapy? Drug Design, Development and Therapy 2018:12 25–40.
  18. Rashidi, S., Mansouri, R., Ali-Hassanzadeh, M., Ghani, E., Karimazar, M.,
  19. Muro, A., and Manzano-Román, R. (2022). miRNAs in the regulation of mTOR signaling and
  20. host immune responses: the case of Leishmania infections. Acta Tropica, 106431.
  21. James, W. D., Elston, D., Treat, J. R., Rosenbach, M. A. and Neuhaus,
  22. I. (2019). Andrews’ Diseases of the Skin E-Book: Clinical Dermatology. Elsevier Health Sciences.
  23. Janardhan, K. S., Jensen, H., Clayton, N. P., and Herbert, R. A. (2018).
  24. Immunohistochemistry in investigative and toxicologic pathology. Toxicologic pathology, 46 (5),
  25. - 510 pp.
  26. Yoo, H. J., Kim, N. Y., and amp; Kim, J. H. (2021, May 31). Current understanding of
  27. the roles of CD1A-restricted T cells in the immune system. Molecules and cells. Retrieved
  28. August 18, 2022.
  29. Behar S, Porcelli SA.(2007). T cell activation by CD1 and lipid antigens.
  30. Springer; CD1-restricted T cells in host defense to infectious diseases. T Cell Activation by CD1
  31. and Lipid Antigens, 215-150 pp.
  32. De Jong, A., and Ogg, G. (2021). CD1a function in human skin disease.
  33. Molecular Immunology, 130, 14-19 pp
  34. Amanzada, A., MalikI, A., Blaschke, M. (2013). Dentification of CD68 (+)
  35. neutrophilgranulocytes in invitro mode ofacute inflammation and inflammatory bowel disease. Nt
  36. J .Cin Exp Pathol ; 6:561570.
  37. Chistiakov, D. A., Killingsworth, M. C., Myasoedova, V. A., Orekhov, A. N., and
  38. Bobryshev, Y. V. (2017). CD68/macrosialin: not just a histochemical marker. Laboratory
  39. investigation, 97(1), 4-13.
  40. Faiz, F. (2021, October 7). CD68 cluster designation 68. University of
  41. Kerbala.RetrieveJuly28,2022,fromhttps://uokerbala.edu.iq/archives/14167
  42. Gregory, D. J., and Olivier, M. (2015). Subversion of host cell signalling by the
  43. protozoan parasite Leishmania. Parasitology, 130 (S1), 27-35 pp.
  44. Wolday, D. ; Akuffo , H. ; Demissie , A. and Britton, S. (2004). Role of Leishmania
  45. donovani and its lipophosphoglycan in CD4+ T-cell activation-induced human
  46. immunodeficiency virus replication. Infect. Immun ., (67): 5258-5264.
  47. AL Lami S.(2021). Epidemiological and diagnostic and genetics study for
  48. leishmania parasite in Misan government. M.Sc. College of Education for pure science.
  49. University of Thi-Qar. 76 pp.
  50. Haghdoust, S., Noroozbeygi, M., Hajimollahoseini, M., Masooleh, M. M.,
  51. and Yeganeh, F. (2022). A candidate vaccine composed of live nonpathogenic Iranian Lizard
  52. Leishmania mixed with Chitin microparticles protects mice against Leishmania major
  53. infection. Acta Tropica, 227, 106298.
  54. Ronet, C., Passelli, K., Charmoy, M., Scarpellino, L., Myburgh, E., La
  55. Torre, Y. H., and Tacchini-Cottier, F. (2019) . TLR2 signaling in skin nonhematopoietic cells
  56. induces early neutrophil recruitment in response to Leishmania major infection. J. Investigative
  57. Dermatology, 139 (6), 318- 328 pp.
  58. Haddy,N.J. (2006). An epidemiological and serological study of visceral leishmaniasis
  59. in Dhi Qar Governorate.( M.Sc thesis,Thi-Qar University).
  60. Khamaes, E. S., Al-Bayati, N. Y., and Abbas, A. H. (2022). Tissue inhibitor
  61. of metalloproteinase-1 (TIMP-1) serum level and genetic polymorphisms associated with
  62. cutaneous Leishmania infections. Human Gene, 33, 201049
  63. Beldi, N., Mansouri, R., Bettaieb, J., Yaacoub, A., Souguir Omrani, H.,
  64. Saadi Ben Aoun, Y. and Guerbouj, S. (2017). Molecular characterization of Leishmania
  65. parasites in Giemsa-stained slides from cases of human cutaneous and visceral leishmaniasis,
  66. Eastern Algeria. Vect. Bor.Z oonot. Di s., 17 (6), 416 – 424 pp.
  67. Ford, J., Hughson, A., Lim, K., Bardina, S. V., Lu, W., Charo, I. F., and
  68. Fowell, D. J. (2019). CCL7 is a negative regulator of cutaneous inflammation following
  69. Leishmania major infection. Frontiers in immunology, 9, 306 .
  70. Al- Al-Mosawi, A, M ,J. (2015,a). Molecular and Immunological Study of
  71. Cutaneous Leishmaniasis in the middle and Southern Provinces PHD thesis ,Kerbala
  72. University.82 pp.
  73. Al-Mosawi, N. AJ. AK. (2015, b) Investigate of Cutaneous Leishmaniasis and
  74. knowledge of the role heat shock protein HSP70 in the immune response in the province of Thi
  75. Qar . M.Sc. College of Education for pure science. University of Thi-Qar. 90 pp.
  76. Schwenkenbecher, J. M., Fröhlich, C., Gehre, F., Schnur, L. F., and Schönian, G.
  77. (2004). Evolution and conservation of microsatellite markers for Leishmania tropica. Infection,
  78. Genetics and Evolution, 4(2), 99-105 pp.
  79. De Carvalho Gallo, J. C., de Mattos Oliveira, L., Araújo, J. S. C.,
  80. Santana, I. B., and dos Santos Junior, M. C. (2018). Virtual screening to identify Leishmania
  81. braziliensis N-myristoyltransferase inhibitors: pharmacophore models, docking, and molecular
  82. dynamics. J. molecular modeling, 24 (9), 1-10 pp.
  83. Passelli, K., Prat-Luri, B., Merlot, M., Goris, M., Mazzone, M., and
  84. Tacchini-Cottier, F. (2022). The c-MET receptor tyrosine kinase contributes to neutrophildriven pathology in cutaneous leishmaniasis. PLoS Pathogens, 18(1), e1010247.
  85. Saravanan, P., Venkatesan, S. K., Mohan, C. G., Patra, S., and Dubey, V.
  86. K. (2010). Mitogen-activated protein kinase 4 of Leishmania parasite as a therapeutic
  87. target. European J.med. chemistry, 45(12), 5662-5670 pp.
  88. Raj, S., Sasidharan, S., Dubey, V. K., and Saudagar, P. (2019). Identification of lead
  89. molecules against potential drug target protein MAPK4 from L. donovani: An in-silico approach
  90. using docking, molecular dynamics and binding free energy calculation. PloS one, 14(8),
  91. e0221331.
  92. Diotallevi, A., Buffi, G., Ceccarelli, M., Neitzke-Abreu, H. C., Gnutzmann,
  93. L. V., Junior, M. S. D. C. L., and Galluzzi, L. (2020). Data on the differentiation among
  94. Leishmania Viannia spp., Leishmania infantum and Leishmania amazonensis in Brazilian clinical
  95. samples using real-time PCR. Data in brief, 28, 104 pp.
  96. Taheri, E., Dabiri, S., Meymandi, M. S., & Saedi, E. (2017). Possible interrelationship
  97. of inflammatory cells in dry type cutaneous leishmaniasis. Iranian Journal of Pathology, 12(2),
  98. Fernandez-Flores A, Rodriguez-Peralto JL.(2016). Morphological and
  99. immunohistochemical clues for the diagnosis of cutaneous leishmaniasis and the interpretation of
  100. CD1a status. J .Am Acad. Dermatol. 74: 536–5pp.
  101. Sundharkrishnan L, (2017). North JP. Histopathologic features of cutaneous
  102. leishmaniasis and use of CD1a staining for amastigotes in Old World and New World
  103. leishmaniasis. J Cutan Pathol. Dec ;44 (12) : 1005-1011 pp.
  104. Farokhpour, F., Rajabi, P., Naeini, B. A., and Naimi, A. (2021). Comparison of
  105. expression of CD1a and CD68 markers in skin leishmaniasis samples with positive and negative
  106. Leishman body. Am. J. Clin and Experimental Immunol 10 (2), 5 pp.
  107. Karabulut YY, Bozkurt FK, Türsen Ü, Bayram G, Temel GÖ, and Erdal
  108. ME. (2021).’The role of CD1a expression in the diagnosis of cutaneous leishmaniasis, its
  109. relationship with leishmania species and clinicopathological features. Dermatol Ther ;34(4) :
  110. e14977.
  111. Gadelha, S. D. A. C., Cunha, M. D. P. S. S. D., Coelho, G. M., Marinho, T.
  112. M. S., and Hirth, C. G. (2019). Evaluation of the diagnostic potential of CD1a
  113. immunohistochemistry for visceral leishmaniasis. Revista do Instituto de Medicina Tropical de
  114. São Paulo, 61 pp.
  115. Khalid,N.D .(2018). systemic and local immuneResponse in individuals
  116. infected with scabies (master thesis,Diyala university) . 134 pp

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