Assessing miR-222-3p and miR-21-5p: Predictive miRNAs for Complications in Gestational Diabetes Mellitus.
DOI:
https://doi.org/10.32792/jmed.2025.29.23Keywords:
Gestationalـdiabetesـmellitus, miR 3 ـ 222 ـ miR ـ 21 ـ 5 p T1DM pAbstract
Usually identified in the second quarter of being pregnant, pregnant diabeticmellitus (G.D.M) becomes a frequent pregnant problem. Mothering diabetic
presents an important medical danger regarding the female as well as the fetus
alongside is linked to pregnancies. There is mounting proof showing that
pregnant women having presentational diabetic type1ـmellitus (T1.DM) as well
as type ـ2 diabetes mellitus (T2.DM) experience greater numbers of serious
pregnancy-related issues than pregnancies women having pregnancy-related
diabetes mellitus (G.D.M). An overview of the current research on miRNAs as
diagnostic biomarkers for pregnant as well as preـgestational diabetes is the goal
of this research project. Methods: One hundred ladies participated in this
research as participants. Between the fifth of September 2024, to the 28th of
May 2025, 50 women with pregnancyـrelated diabetes visited the diabetic
consulting clinics at the Maternals & KidsـEducationalـHospital located within
Al-Diwaniyah Province. Medically historical events testing in the lab
(HbA.1cـtest), as well as fasting evaluations were used for diagnosing
individuals with pregnancy-related diabetes. Results: During the present
research, the gene expression of comparative mi.RNA222 as well as the level of
expression within the participants in the G.D.Mـgroup as well as the presumably
controls were quantitatively examined using RTـPCR. Additionally, a
mathematical RT-PCR examination for comparing miRNA222 expressing
themselves was conducted in the present research compared the set of
participants GDM as well as the controls, ostensibly. Conclusion: Owing to this
research, miR5-21-p might be a useful biomarker for G.D.M. Additionally,
miR3ـ222ـp seems to have a positive correlation between fasting plasma glucose,
confirming its function in metabolizingـglucose, whereas miR-21 may affect
resistant to insulin as well as the absorption of glucose.
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