Main Article Content
Abstract
domains. Statistical analysis was performed by using SPSS through chi-square, Mann-Whitney, and Kruskal-Wallis tests. Results: The majority of participants were female (76.9%) and aged between 36–55 years. The total thyroidectomy group showed a significantly higher rate of postoperative complications (p = 0.013), with seroma and hypocalcemia being the most frequent. Total thyroidectomy was also associated with significantly higher impairment in physical (p < 0.001), emotional (p = 0.003), and social (p = 0.007) quality of life domains. Conclusion: Patients having a total thyroidectomy reported decreased quality of life and more postoperative complications than those having a partial thyroidectomy. These results emphasize the importance of surgical decisionmaking and the need for accurate preoperative counseling, especially with relation to expected outcomes and QoL effects.
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Copyright (c) 2025 Pavel Mustafa Kareem , Delan Jamal Qader

This work is licensed under a Creative Commons Attribution 4.0 International License.
References
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References
Shulhai AM, Rotondo R, Petraroli M, Patianna V, Predieri B, Iughetti L, et al. The Role of Nutrition on Thyroid Function. Vol. 16,
Nutrients. Multidisciplinary Digital Publishing Institute (MDPI); 2024. doi: 10.3390/nu16152496
Maniakas A, Davies L, Zafereo ME. Thyroid Disease Around the World. Vol. 51, Otolaryngologic Clinics of North America. 2018.
Doi: 10.1016/j.otc.2018.01.014
Jin S, Sugitani I. Narrative review of management of thyroid surgery complications. Gland Surg. 2021;10(3). Doi: 10.21037/gs-20
Gerardi I, Verro B, Amodei R, Richiusa P, Saraniti C. Thyroidectomy and Its Complications: A Comprehensive Analysis.Biomedicines. 2025 Feb 1;13(2).doi: 10.3390/biomedicines13020433
Fu Y, Shi W, Zhao J, Cao X, Cao Y, Lei M, et al. Prediction of postoperative health-related quality of life among patients with
metastatic spinal cord compression secondary to lung cancer. Front Endocrinol (Lausanne). 2023;14. doi: 10.3389/fendo.2023.1206840
Alnefaie SM, Alotaibi MS, Alsobaie AE, Alotaibi WB, Alwuthaynani MI, Alotibi AR, et al. Assessment of Patients’ Quality-of Life Post-Thyroidectomy.Cureus. 2024; doi: 10.7759/cureus.52744
Landry V, Siciliani E, Henry M, Payne RJ. Health-Related Quality of Life Following Total Thyroidectomy and Lobectomy for
Differentiated Thyroid Carcinoma: A Systematic Review. Vol. 29, Current Oncology. 2022. doi: 10.3390/curroncol29070350
Chahardahmasumi E, Salehidoost R, Amini M, Aminorroaya A, Rezvanian H, Kachooei A, et al. Assessment of the Early and Late
Complication after Thyroidectomy. Adv Biomed Res. 2019;8(1). doi: 10.4103/abr.abr_3_19
Hsiao V, Light TJ, Adil AA, Tao M, Chiu AS, Hitchcock M, et al. Complication Rates of Total Thyroidectomy vs Hemithyroidectomy for Treatment of Papillary Thyroid Microcarcinoma: A Systematic Review and Meta-analysis. Vol. 148, JAMA Otolaryngology - Head and Neck Surgery. 2022. doi: 10.1001/jamaoto.2022.0621
Chen W, Li J, Peng S, Hong S, Xu H, Lin B, et al. Association of Total Thyroidectomy or Thyroid Lobectomy with the Quality of
Life in Patients with Differentiated Thyroid Cancer with Low to Intermediate Risk of Recurrence. JAMA Surg. 2022;157(3). doi:1001/jamasurg.2021.6442
Yaniv D, Vainer I, Amir I, Robenshtok E, Hirsch D, Watt T, et al. Quality of life following lobectomy versus total thyroidectomy is significantly related to hypothyroidism. J Surg Oncol. 2022;126(4). doi: 10.1002/jso.26983
ÇETİN ASLAN E, ASLAN H. A CROSS-SECTIONAL ASSESSMENT ON THE THYROIDECTOMY PROCEDURES IN TURKEY. Karya Journal of Health Science. 2022;3(3). doi: 10.52831/kjhs.1173079
Mahmood AS, Reyadh AR, Shareef BQ, Albu-Rghaif AH, Al-hussaniy HA, Naji MA. Increasing Prevalence of Congenital Hypothyroidism in children with Down Syndrome who have a family history of Thyroid disease. Res J Pharm Technol. 2023;16(3). doi: 10.52711/0974-360X.2023.00218
Mulita F, Verras GI, Dafnomili VD, Tchabashvili L, Perdikaris I, Bousis D, et al. Thyroidectomy for the Management of Differentiated Thyroid Carcinoma and their Outcome on Early Postoperative Complications: A 6-year Single-Centre Retrospective Study. In: Chirurgia (Romania). 2022. doi: 10.21614/chirurgia.2736
Willobee BA, Huerta CT, Quiroz HJ, Mao ML, Ryon EL, Ferrantella A, et al. Higher Complication Rates for Total versus Partial
Thyroidectomy in the Pediatric Population. Journal of Surgical Research. 2023;283. doi: 10.1016/j.jss.2022.10.074
Al Sadder KA, Ali N, Alsharekh S, Mazen B, Alqaysi L, Alhabib R, et al. A Comparison Between Complications Following Total
Versus Subtotal Thyroidectomy: A Literature Review. JOURNAL OF HEALTHCARE SCIENCES. 2022;02(04):58–66. doi: 52533/johs.2022.2403
Ha EJ, Lee J. The effect of fibrin glue on the quantity of drainage after thyroidectomy: a randomized controlled pilot trial. Ann Surg Treat Res. 2022;102(4). doi: 10.4174/astr.2022.102.4.177
Abothenain F* BAASAA and AS. Seroma as an Unusual Complication Post Total Thyroidectomy Managed with a Special Technique: Case Report OPEN ACCESS. 2020.
Azadbakht M, Emadi-jamali SM, Azadbakht S. Hypocalcemia following total and subtotal thyroidectomy and associated factors.
Annals of Medicine and Surgery. 2021;66.
Mirghani H, Altedlawi Albalawi IA. The Ongoing Debate Regarding Completion Thyroidectomy Versus Primary Thyroid Surgery
for Low and Intermediate Differentiated Thyroid Carcinoma: A Meta-Analysis. Cureus. 2020; doi: 10.7759/cureus.12033
Fan C, Zhou X, Su G, Zhou Y, Su J, Luo M, et al. Risk factors for neck hematoma requiring surgical re-intervention after thyroidectomy: A systematic review and meta-analysis. Vol. 19, BMC Surgery. 2019. doi: 10.1186/s12893-019-0559-8
Vicente DA, Solomon NP, Avital I, Henry LR, Howard RS, Helou LB, et al. Voice outcomes after total thyroidectomy, partial
thyroidectomy, or non-neck surgery using a prospective multifactorial assessment. J Am Coll Surg. 2014;219(1). doi: 1016/j.jamcollsurg.2014.03.019
Lang BHH, Wong CKH, Ma EPM. A systematic review and meta-analysis on acoustic voice parameters after uncomplicated
thyroidectomy. Vol. 126, Laryngoscope. 2016. doi: 10.1002/lary.25452
Ciftci F, Sakalli E, Abdurrahman I. Total versus bilateral subtotal thyroidectomy for benign multi-nodular goiter. Int J Clin Exp
Med. 2015;8(3).
Hughes DT, Reyes-Gastelum D, Kovatch KJ, Hamilton AS, Ward KC, Haymart MR. Energy level and fatigue after surgery for
thyroid cancer: A population-based study of patient-reported outcomes. In: Surgery (United States). 2020. doi: 1016/j.surg.2019.04.068
Maki Y, Horiuchi K, Okamoto T. Fatigue and quality of life among thyroid cancer survivors without persistent or recurrent disease. Endocr Connect. 2022;11(2). doi: 10.1530/EC-21-0506
Park YM, Oh KH, Cho JG, Baek SK, Kwon SY, Jung KY, et al. Changes in Voice- and Swallowing-Related Symptoms After
Thyroidectomy: One-Year Follow-Up Study. Annals of Otology, Rhinology and Laryngology. 2018;127(3). doi: 1177/0003489417751472
Maraş Baydoğan G, Sürme Y, Kütük Karasungur S. Determinants of Quality of Life in Patients After Thyroidectomy: Electrolyte
Imbalance, Sleep Problems, and Fatigue. İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi [Internet]. 2025 Apr 29;(25):166–79.
Available from: https://dergipark.org.tr/en/doi/10.38079/igusabder.1602553
Bongers PJ, Greenberg CA, Hsiao R, Vermeer M, Vriens MR, Lutke Holzik MF, et al. Differences in long-term quality of life
between hemithyroidectomy and total thyroidectomy in patients treated for low-risk differentiated thyroid carcinoma. In: Surgery (United States). 2020. doi: 10.1016/j.jss.2021.02.039
Nakamura T, Miyauchi A, Ito Y, Ito M, Kudo T, Tanaka M, et al. Quality of life in patients with low-risk papillary thyroid
microcarcinoma: Active surveillance versus immediate surgery. Endocrine Practice. 2020;26(12). doi: 10.4158/EP-2020-0201
Król A, Grochowska A, Bodys-Cupak I, Łabuzek M, Kołpa M. Quality of life of patients after total and subtotal thyroidectomy.
Health Promotion & Physical Activity. 2020;12(3). doi: 10.5604/01.3001.0014.4324
Lan Y, Cao L, Song Q, Jin Z, Xiao J, Yan L, et al. The quality of life in papillary thyroid microcarcinoma patients undergoing
lobectomy or total thyroidectomy: A cross-sectional study. Cancer Med. 2021;10(6). doi: 10.1002/cam4.3747
van Gerwen M, Cooke P V., Alpert N, Mols F, Genden E, Schwartz RM. Patient-reported outcomes following total thyroidectomy
and lobectomy in thyroid cancer survivors: an analysis of the PROFILES Registry data. Supportive Care in Cancer. 2022;30(1). doi: 1007/s00520-021-06355-x
Chen S, Hu X, Yang P, Yang L, Peng S, He L, et al. Status of mental and social activities of young and middle-aged patients after
papillary thyroid cancer surgery. Front Oncol. 2024;14. doi: 10.3389/fonc.2024.1338216
