Assessment of Atrial natriuretic peptide serum level in patients with polycystic ovary syndrome in Iraqi population
DOI:
https://doi.org/10.32792/jmed.2025.29.37Keywords:
PCOS, ANP, insulin resistance, hyperandrogenism, and corinAbstract
Background: Polycystic ovarian syndrome is a prevalent metabolic condition inwomen of reproductive age. The prevalence rate is approximately 9% among
women of reproductive age. This study sought to assess the levels of atrial
natriuretic peptide in patients with PCOS and its correlation with insulin
resistance and hyperandrogenism.
Methods: 60 patients with PCOS were screened to be suitable for participation in
this study, aged from 19 to 45. They were attended to at the outpatient clinic, as
well as 30 healthy women as a control group. Serum levels of insulin, testosterone,
and corin were estimated using an ELISA kit, as well as glucose, FSH, LH, and
HbA1c.
Results: The present study revealed that there are no significant differences in
ANP serum level between PCOS patients and the healthy control group. As well
as it showed an increase in the corin levels, although corin is part of its function,
which is to activate the ANP. In addition, the study demonstrated that the plasma
ANP was directly correlated with insulin resistance and the LH/FSH ratio.
Conclusions: The results of this study emphasize the importance of NP and Corin
serum levels in women with PCOS. Our data suggest that circulating corin reflects
the metabolic abnormalities of PCOS patients. We also discovered a robust
positive association between the ANP level and insulin resistance.
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