Article Sidebar

Submitted
December 24, 2025
Accepted
December 24, 2025
Published
December 14, 2025
Download
PDF
Statistic
Read Counter : 186 Download : 104

Main Article Content

Abstract

Background: Polycystic ovarian syndrome is a prevalent metabolic condition in
women of reproductive age. The prevalence rate is approximately 9% among
women of reproductive age. This study sought to assess the levels of atrial
natriuretic peptide in patients with PCOS and its correlation with insulin
resistance and hyperandrogenism.
Methods: 60 patients with PCOS were screened to be suitable for participation in
this study, aged from 19 to 45. They were attended to at the outpatient clinic, as
well as 30 healthy women as a control group. Serum levels of insulin, testosterone,
and corin were estimated using an ELISA kit, as well as glucose, FSH, LH, and
HbA1c.
Results: The present study revealed that there are no significant differences in
ANP serum level between PCOS patients and the healthy control group. As well
as it showed an increase in the corin levels, although corin is part of its function,
which is to activate the ANP. In addition, the study demonstrated that the plasma
ANP was directly correlated with insulin resistance and the LH/FSH ratio.
Conclusions: The results of this study emphasize the importance of NP and Corin
serum levels in women with PCOS. Our data suggest that circulating corin reflects
the metabolic abnormalities of PCOS patients. We also discovered a robust
positive association between the ANP level and insulin resistance.

Keywords

PCOS ANP insulin resistance hyperandrogenism, and corin

Article Details

License

Copyright (c) 2025 admin; Maryam Ahmed Abdulrahman, Sami . A. Zbaar

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

References

  1. Bednarska S, Siejka A. The pathogenesis and treatment of polycystic ovary syndrome: What’s new? Adv Clin Exp Med.
  2. ;26(2):359–67.
  3. Kumarendran B, O’Reilly MW, Manolopoulos KN, Toulis KA, Gokhale KM, Sitch AJ, et al. Polycystic ovary syndrome, androgen
  4. excess, and the risk of nonalcoholic fatty liver disease in women: A longitudinal study based on a United Kingdom primary care
  5. database. PLoS Med. 2018;15(3):1–20.
  6. Maria Trent, Catherine M. Gordon; Diagnosis and Management of Polycystic Ovary Syndrome in Adolescents. Pediatrics May
  7. ; 145 (Supplement_2): S210–S218. 10.1542/peds.2019-2056J
  8. Huo Y, Ji S, Yang H, Wu W, Yu L, Ren Y, Wang F. Differential expression of microRNA in the serum of patients with polycystic
  9. ovary syndrome with insulin resistance. Ann Transl Med 2022;10(14):762.
  10. Semenov AG, Tamm NN, Seferian NN, Postnikov KR, Karpova AB, Serebryanaya NS, Koshkina DV, Krasnoselsky EV, Katrukha
  11. MI. Processing of pro-B-type natriuretic peptide: furin and Corin as candidate convertases. Clin Chem. 2010;56(7):1166–76.
  12. Zhang X, Gu X, Zhang Y, Dong N, Wu Q. Corin: a key mediator in sodium homeostasis, vascular remodeling, and heart failure.
  13. Biology. 2022;11(5):717.
  14. Yu R, Han X, Zhang X, Wang Y, Wang T. Circulating soluble corin as a potential biomarker for cardiovascular diseases: a trans
  15. lational review. Clin Chim Acta. 2018; 485:106–12.
  16. Sami A. Zbaar, Sawsan S. Hosi, Doaa Sabeeh Al-Nuaimi. Association of Nestatin1 resistance in obese adolescents of Iraq population.
  17. Gorgian medical news. 2023:No10 (343) 107-110
  18. Trummer C, Schwetz V, Giuliani A, Obermayer-Pietsch B, Lerchbaum E. Impact of elevated thyroid-stimulating hormone levels in
  19. polycystic ovary syndrome. Gynecol Endocrinol. 2015;31(10):819–23.
  20. Omer ZS, Ahmied MS, Yaqoub NK. Relation of visfatin and polycystic ovarian syndrome in women. Med J Babylon.
  21. ;15(4):316.
  22. Alaa Wageh, Maha Houssen , Ahmed Gibreel , Mohamed Sayed Abdelhafez , Mona Abo-bakr El-Hussiny , Ola Ali Elemam , Noha
  23. El-Adawi. Serum atrial natriuretic peptide levels among clomiphene citrate resistant polycystic ovarian syndrome patients. Middle East
  24. Fertility Society Journal. Volume 23, Issue 4, December 2018, Pages 370-372
  25. Lauria PB, Del Puerto HL, Reis AM, Candido AL, Reis FM. Low plasma atrial natriuretic peptide: a new piece in the puzzle of
  26. polycystic ovary syndrome. J Clin Endocrinol Metab 2013; 98: 4882–4889 .
  27. J. Dineva, I. Vangelov, G. Nikolov, D. Gulenova, M. Ivanova. Atrial natriuretic peptide is an antiapoptotic factor for human
  28. granulosa luteinized cells with impact on the results of COH/IVF in women undergoing IVF program J. Obstet. Gynaecol. Res., 37 (6)
  29. (2011), pp. 511-519
  30. Misono KS, Philo JS, Arakawa T, Ogata CM, Qiu Y, Ogawa H et al. Structure, signaling mechanism and regulation of the natriuretic
  31. peptide receptor guanylate cyclase. FEBS J 2011; 278: 1818–1829
  32. Song W, Wang H, Wu Q. Atrial natriuretic peptide in cardiovascular biology and disease (NPPA). Gene 2015; 569: 1–6[ .
  33. Dineva J, Vangelov I, Nikolov G, Gulenova D, Ivanova M. Atrial natriuretic peptide is an antiapoptotic factor for human granulosa
  34. luteinized cells with impact on the results of COH/IVF in women undergoing IVF program. J Obstet Gynaecol Res 2011; 37: 511519].
  35. Qin Zheng , Yulin Li , Dandan Zhang , Xinyuan Cui , Kuixing Dai , Yu Yang , Shuai Liu , Jichun Tan , Qiu Yan. ANP promotes
  36. proliferation and inhibits apoptosis of ovarian granulosa cells by NPRA/PGRMC1/EGFR complex and improves ovary functions of
  37. PCOS rats. Cell Death Dis. 2017 Oct 26;8(10):e3145
  38. Gutkowska J, Jankowski M, Sairam MR, Fujio N, Reis AM, Mukaddam-Daher S et al. Hormonal regulation of natriuretic peptide
  39. system during induced ovarian follicular development in the rat. Biol Reprod 1999; 61: 162–170
  40. Song, E. et al. Cardiac autophagy deficiency attenuates ANP production and disrupts myocardial-adipose cross talk, leading to
  41. increased fat accumulation and metabolic dysfunction. Diabetes (2021): 70, 51–61
  42. Miyashita, K. et al. Natriuretic peptides/cGMP/cGMP-dependent protein kinase cascades promote muscle mitochondrial biogenesis
  43. and prevent obesity. Diabetes. 2009: 58, 2880–2892.20. Meiting Xue, Yue Shi, Aiming Pang, Li Men, Yahui Hu, Pengfei Zhou,
  44. Guangfeng Long. Corin plays a protective role via upregulating MAPK and downregulating eNOS in diabetic nephropathy endothelial
  45. dysfunction. FASEP j.2020. VOL.24.1: 95-106
  46. 73. Peng H, Zhang Q, Shen H, Liu Y, Chao X, Tian H, Cai X, Jin J. Association between serum soluble Corin and obesity in
  47. Chinese adults: a cross-sectional study. Obesity. 2015;23(4):856–61.
  48. Le MT, Le VN, Le DD, Nguyen VQ, Chen C, Cao NT. Exploration of the role of anti-mullerian hormone and LH/FSH ratio in the
  49. diagnosis of polycystic ovary syndrome. Clin Endocrinol. 2019;90(4):579–85.
  50. . Chen S, Jiang M, Ding T, Wang J, Long P. Calprotectin is a potential prognostic marker for polycystic ovary syndrome. Ann
  51. Clin Biochem. 2017;54(2):253–7.
  52. . Vatier C, Christin-Maitre S, Vigouroux C. Role of insulin resistance on fertility–Focus on polycystic ovary syndrome. Ann
  53. Endocrinol (Paris). 2022;83(3):199-202.

Similar Articles

You may also start an advanced similarity search for this article.