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October 20, 2024
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October 20, 2024
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October 21, 2024
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Abstract

Background: Cytokines are important in autoimmune thyroid disease. Interleukins regulate
immunity. Lack impairs immunity or causes autoimmune disorders. This study is aiming to
investigate whether inflammatory cytokines (IL-6, TNF-α) levels in the blood correlate with
Hashimoto thyroiditis.
Methods: In this study, we used an ELISA device to determine the levels of interleukins in the
serum of 60 patients with Hashimoto's disease and 60 people as a control group. We diagnosed the
patients based on their clinical condition and also examined their thyroid function and antibodies.
Results: According to the research findings, individuals with Hashimoto's thyroiditis had
considerably higher levels of IL6 and TNF-α (P < 0.001) and could be used to tell the difference
between HT patients and healthy people in the AUC analysis. A positive correlation between
(antiTPO, antiTG, TSH) levels and (IL6, TNF-α) levels has also been demonstrated, which may
indicate that these changes play a role in the development of HT.
Conclusions: This study clearly established that the levels of IL6, TNF alpha is strongly related
with the risk of HT in individuals in Najaf Province, Iraq

Keywords

autoimmune thyroid disease AITD Hashimoto’s thyroiditis HT interleukins

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