Article Sidebar
Main Article Content
Abstract
highly prevalent virus that infects a significant majority of individuals worldwide at some point in
their lifetime. HCMV induces a cascade of inflammatory reactions that can result in cellular
damage and play a role in the initiation and advancement of diverse inflammatory conditions.
Inflammation is a significant determinant for diabetes (diabetes mellitus) and plays a crucial role
in the onset and development of various complications associated with diabetes.
Methods: This study included the collection of serum samples for the detection of Human
cytomegalovirus antibodies in 200 patients with diabetes type 2. Also included was a control
group consisting of 100 individuals of different ages who did not have diabetes. The period of
collecting sample was from August 2023 to October 2023. All these serum samples are detected
for Human cytomegalovirus antibodies by the enzyme-linked immunosorbent assay method.
Conclusions: According to the results of this study, there was a significant difference in term of
anti-human cytomegalovirus IgG antibody between diabetic type 2 patients and control and also
there was a high significant difference in term of anti-human cytomegalovirus IgM antibody
between those patients and control group. It was also found that there are no significant
differences in the detection of anti-human cytomegalovirus IgM antibody among patients in terms
of sex, age, residency and family history.
Keywords
Article Details
Copyright (c) 2024 University of Thi-Qar Journal Of Medicine
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
References
- Abdalla MM. Relationship between Cytomegalovirus (CMV) and Breast Cancer among
- Sudanese's Ladies in Khartoum State [PhD dissertation]. [Faculty of Graduate Studies and
- Scientific Research]: University of Shendi; 2018.
- Fall C, El Faiz MC, Ennaji MM, Bennani B. Cytomegalovirus: An Oncomodulator and
- Therapeutic Target in Glioma Management. InEmerging and Reemerging Viral Pathogens 2020
- Jan 1 (pp. 253-275). Academic Press.
- Morozov VA, Morozov AV, Denner J. New PCR diagnostic systems for the detection and
- quantification of porcine cytomegalovirus (PCMV). Archives of virology. 2016 May;161:115968.
- Schleiss MR. Cytomegalovirus. In Maternal Immunization 2020 Jan 1 (pp. 253-288).
- Academic Press.
- Lazim HH, Kadhim HS. Review of sero-prevalence of human cytomegalovirus in Iraq. J
- Microbiol Exp. 2018;6(2):50-5.
- Elder E, Sinclair J. HCMV latency: what regulates the regulators?. Medical microbiology
- and immunology. 2019 Aug 1;208:431-8.
- Griffiths P, Reeves M. Pathogenesis of human cytomegalovirus in the
- immunocompromised host. Nature Reviews Microbiology. 2021 Dec;19(12):759-73.
- Galicia-Garcia U, Benito-Vicente A, Jebari S, Larrea-Sebal A, Siddiqi H, Uribe KB,
- Ostolaza H, Martín C. Pathophysiology of type 2 diabetes mellitus. International journal of
- molecular sciences. 2020 Aug 30;21(17):6275.
- Hasan HM, Salloom DF. Human Cytomegalovirus Infection as a Risk Factor for Type 2
- Diabetes Mellitus Development in a Sample of Iraqi Patients. Medico-Legal Update. 2021 Apr
- ;21(2).
- Zhang J, Liu YY, Sun HL, Li S, Xiong HR, Yang ZQ, Jiang XJ. High human
- cytomegalovirus IgG level is associated with increased incidence of diabetic atherosclerosis in
- type 2 diabetes mellitus patients. Medical science monitor: international medical journal of
- experimental and clinical research. 2015;21:4102.
- Wensveen TT, Gašparini D, Rahelić D, Wensveen FM. Type 2 diabetes and viral
- infection; cause and effect of disease. diabetes research and clinical practice. 2021 Feb
- ;172:108637.
- Ahmed MA. Seroprevalence of Cytomegalovirus among type 2 diabetic patients in Zinam
- Specialist Hospital in Khartoum State [PhD dissertation]. [College of Graduate Studies]: Sudan
- University of Science & Technology; 2015.
- Yoo SG, Do Han K, Lee KH, La Y, Han SH. Impact of cytomegalovirus disease on newonset type 2 diabetes mellitus: population-based matched case-control cohort study. Diabetes &
- metabolism journal. 2019 Dec;43(6):815.
- Abdul-Kadir Zaman N. Serological Study of Human Cytomegalovirus (CMV) in Diabetic
- Patients in Kirkuk Governorate. Kirkuk University Journal-Scientific Studies. 2015 Mar
- ;10(1):58-70.
- Al-Heidery ZH, Abbas HH, Yasir SJ. Screening of human cytomegalovirus (CMV) in
- diabetic patients in Najaf governorate. Medical Journal of Babylon. 2013;10(1).
- AI-Nafakh RT, Yasir SJ, AL-Fadhul SA, Hassan ES. Cytomegalovirus infection and
- glutamic acid decarboxylase antibodies in type 2 diabetic patients. Pak J Medd Health Sci.
- ;14:450
References
Abdalla MM. Relationship between Cytomegalovirus (CMV) and Breast Cancer among
Sudanese's Ladies in Khartoum State [PhD dissertation]. [Faculty of Graduate Studies and
Scientific Research]: University of Shendi; 2018.
Fall C, El Faiz MC, Ennaji MM, Bennani B. Cytomegalovirus: An Oncomodulator and
Therapeutic Target in Glioma Management. InEmerging and Reemerging Viral Pathogens 2020
Jan 1 (pp. 253-275). Academic Press.
Morozov VA, Morozov AV, Denner J. New PCR diagnostic systems for the detection and
quantification of porcine cytomegalovirus (PCMV). Archives of virology. 2016 May;161:115968.
Schleiss MR. Cytomegalovirus. In Maternal Immunization 2020 Jan 1 (pp. 253-288).
Academic Press.
Lazim HH, Kadhim HS. Review of sero-prevalence of human cytomegalovirus in Iraq. J
Microbiol Exp. 2018;6(2):50-5.
Elder E, Sinclair J. HCMV latency: what regulates the regulators?. Medical microbiology
and immunology. 2019 Aug 1;208:431-8.
Griffiths P, Reeves M. Pathogenesis of human cytomegalovirus in the
immunocompromised host. Nature Reviews Microbiology. 2021 Dec;19(12):759-73.
Galicia-Garcia U, Benito-Vicente A, Jebari S, Larrea-Sebal A, Siddiqi H, Uribe KB,
Ostolaza H, Martín C. Pathophysiology of type 2 diabetes mellitus. International journal of
molecular sciences. 2020 Aug 30;21(17):6275.
Hasan HM, Salloom DF. Human Cytomegalovirus Infection as a Risk Factor for Type 2
Diabetes Mellitus Development in a Sample of Iraqi Patients. Medico-Legal Update. 2021 Apr
;21(2).
Zhang J, Liu YY, Sun HL, Li S, Xiong HR, Yang ZQ, Jiang XJ. High human
cytomegalovirus IgG level is associated with increased incidence of diabetic atherosclerosis in
type 2 diabetes mellitus patients. Medical science monitor: international medical journal of
experimental and clinical research. 2015;21:4102.
Wensveen TT, Gašparini D, Rahelić D, Wensveen FM. Type 2 diabetes and viral
infection; cause and effect of disease. diabetes research and clinical practice. 2021 Feb
;172:108637.
Ahmed MA. Seroprevalence of Cytomegalovirus among type 2 diabetic patients in Zinam
Specialist Hospital in Khartoum State [PhD dissertation]. [College of Graduate Studies]: Sudan
University of Science & Technology; 2015.
Yoo SG, Do Han K, Lee KH, La Y, Han SH. Impact of cytomegalovirus disease on newonset type 2 diabetes mellitus: population-based matched case-control cohort study. Diabetes &
metabolism journal. 2019 Dec;43(6):815.
Abdul-Kadir Zaman N. Serological Study of Human Cytomegalovirus (CMV) in Diabetic
Patients in Kirkuk Governorate. Kirkuk University Journal-Scientific Studies. 2015 Mar
;10(1):58-70.
Al-Heidery ZH, Abbas HH, Yasir SJ. Screening of human cytomegalovirus (CMV) in
diabetic patients in Najaf governorate. Medical Journal of Babylon. 2013;10(1).
AI-Nafakh RT, Yasir SJ, AL-Fadhul SA, Hassan ES. Cytomegalovirus infection and
glutamic acid decarboxylase antibodies in type 2 diabetic patients. Pak J Medd Health Sci.
;14:450